Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum
نویسندگان
چکیده
منابع مشابه
Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum.
Anaplasma phagocytophilum persists in nature by cycling between mammals and ticks. Human infection by the bite of an infected tick leads to a potentially fatal emerging disease called human granulocytic anaplasmosis. A. phagocytophilum is an obligatory intracellular bacterium that replicates inside mammalian granulocytes and the salivary gland and midgut cells of ticks. A. phagocytophilum evolv...
متن کاملCavitary Effusion Associated with Anaplasma phagocytophilum Infection in 2 Equids
A 15-year-old, 558-kg Quarter Horse gelding was examined because of peripheral edema and bicavitary (pleural and abdominal) effusion, identified via field ultrasonography before referral. Two years earlier, the horse was evaluated for a similar clinical presentation, including peripheral edema, bicavitary effusion, and fever. The gelding was diagnosed with Anaplasma phagocytophilum infection by...
متن کاملStat1 negatively regulates immune-mediated injury with Anaplasma phagocytophilum infection.
Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium Anaplasma phagocytophilum. Our data previously demonstrated that A. phagocytophilum induces an immunopathologic response by activating IFN-γ production through the Stat1 signaling pathway. In this study, we investigated the broader role of Stat1 signaling in the host response to infection with A. phagocytoph...
متن کاملTransformation of Anaplasma phagocytophilum
BACKGROUND Tick-borne pathogens cause emerging zoonoses, and include fastidious organisms such as Anaplasma phagocytophilum. Because of their obligate intracellular nature, methods for mutagenesis and transformation have not been available. RESULTS To facilitate genetic manipulation, we transformed A. phagocytophilum (Ap) to express a green fluorescent protein (GFP) with the Himar1 transposas...
متن کاملEarly transcriptional response of human neutrophils to Anaplasma phagocytophilum infection.
Anaplasma phagocytophilum, an unusual obligate intracellular pathogen that persists within neutrophils, causes human anaplasmosis (previously known as human granulocytic ehrlichiosis). To study the effects of this pathogen on the transcriptional profile of its host cell, we performed a comprehensive DNA microarray analysis of the early (4-h) transcriptional response of human neutrophils to A. p...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2011
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00064-10